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NMR Console

Welcome to the UCSF NMR Lab

Our state-of-the-art facilities enable detailed studies of structure and dynamics in proteins, RNA, and small molecules as well as interactions between those molecules. Most studies entail purified molecular components, but cellular systems can also be investigated.

VNMR Software

The UCSF Nuclear Magnetic Resonance Laboratory

The UCSF NMR Lab provides a range of state-of-the-art NMR facilities that are available for use by qualified academic and outside researchers.

Besides experiments to identify and determine the structure of small organic molecules, the high-field NMR spectrometers (ranging from 400 to 800 MHz for 1H NMR) are capable of protein and RNA structure determination. This is accomplished via heteronuclear (e.g., 1H, 13C, 15N, 31P) multi-dimensional NMR spectra, often using locally written and widely distributed software (e.g., Sparky, MARDIGRAS, CORMA) for data analysis.

Various methods are available for study of many types of dynamics, ranging from conformational flexibility on many timescales to reaction dynamics. Moderately high-throughput identification of small molecule ligands that bind to a target protein or RNA is abetted by an automatic sample changer.

Affiliations and Location

The Nuclear Magnetic Resonance (NMR) Spectroscopy Lab is administered by the Dept. of Pharmaceutical Chemistry, UCSF School of Pharmacy.

It is located in Rooms S102 and S106 in Genentech Hall on the Mission Bay Campus of UCSF.

Visit our instruments section for more information about our equipment.